Even if it’s a speech, talk with, not at. It’s a stance, a tone, a shift in perspective that can make an audience of hundreds feel like the speaker is with them, connecting directly and personally.
Ask questions. Move. Make eye contact. Feel what they are feeling. Be with the audience.
And how much more important this is in dialogue, with your friend, a colleague, your boss, your spouse, your child. Talk with, not at.